"I can only defend myself against the wart section :) In wart the pipe operator can only take two args and is intended to be used in infix. I use a non-infix transform for more args, and prefix mode in general"
Oh, so you're pursuing both options at once. I look forward to you figuring out what kind of indentation you prefer here. :) My "considerations about wart" section was only wishy-washy anyway.
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"For the rest, my weak defense is that functionize and the _ syntax is only intended for tiny expressions."
In Penknife, when I used the a'b operator as sugar for (b a), I found I ended up with a few really long lines of a.b.c'd'e.f, so it kinda suffered from its own success. ^_^ My a'b is the same as your (a -> b._), and it exactly corresponds to your no-underscore special case, (a -> b), so I expect you to have the same issue.
I suspect these syntaxes actually have a special tendency to let sugar accumulate, driving them away from the ideal "tiny expressions" case. Specifically, they make it possible to inject new code without breaking apart the surrounding sugar first:
a.b.f.c.d # before refactoring
a.b."foo".c.d # illegal
a.b -> (_ "foo") -> _.c.d # legal? (not quite the example you gave)
a.b'[itfn:it s.foo].c.d # Penknife code of similar generality
Fortunately for wart, its infix operators allow whitespace in between, which possibly means you can write these long expressions on multiple lines. (That wasn't the case in Penknife.)